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Scrambler Therapy® (ST) is a non-invasive electro-analgesia therapy based on a new generation of medical device that uses 5 artificial neurons and an autonomous theoretical model that differs from Gate Control Theory. The active principle with ST is such that synthetic “non-pain” information is transmitted by C fibers surface receptors. Therefore, the traditional electric stimulation of A-Beta fibers to produce paresthesia and/or block the conduction of nerve fibers to produce an analgesic effect, i.e., via TENS/SCS machines, is abandoned.
ST was developed to treat chronic neuropathic pain and cancer pain resistant to opioids and other types of treatments. The goal of ST is to eliminate pain during treatment, and allow for long lasting good analgesia after a cycle of 10 to 12 consecutive treatments performed over a period of two weeks. Scrambler Therapy® (ST) has been specifically developed for pain resistant to any type of treatment including opioids. Published clinical trials have enrolled patients non-responsive to other protocol treatments. Considering the follow up efficacy in neuropathic pain, ST is an effective treatment. In acute pain, not its envisaged application field, ST can be used as a symptomatic therapy. This makes it a good fit to use in place of opioid-based therapies.
The Scrambler Therapy® Device is based on 5 artificial neurons which were developed to non-invasively transmit information recognizable as "self" and "non pain" to the central nervous system (CNS). The electrical stimulus is specifically designed to excite C fibres by using pulses with an appropriate width. Other properties of form / function / modulation allow the encoding of information strings able to substitute pain information with synthetic "non-pain" information. This was done by digitally synthesizing different main kinds of action potentials with variable geometry, very similar to the endogenous kind, which produce different perception effects depending on the string-sequence in which they are assembled over time and how they are modulated. An algorithm dynamically generates this specific strings of "no pain" information, in order to achieve the goal of immediate and complete analgesia, re-modulation of the pain system, a high level of safety and long-term efficacy.
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