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Model 2: Entropy in chronic phatological processes

Disease may be defined as the result of the breakdown of homeostatic equilibrium and the functional reserve as the complex means by which it may be restored and maintained.

Any conflict between the energy required for the various functions and the available energy affects the efficiency of the functional reserve and thus the possibility of the cell to perform activities greater than those performed under normal conditions whenever the reserve has to be increased. In the case of a chronic event, the functional reserve is constantly drawn upon and, as a result of the DeltaSrs, tends gradually to push the system slowly but irreversibly towards a thermodynamically more probable state, that is, one of greater disorder, which corresponds to the clinical progress of the pathology.


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