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Oncological and Neuropathic Pain - Selected References


Review

Chwistek M. Recent advances in understanding and managing cancer pain. F1000Res. 2017 Jun 20;6:945. doi: 10.12688/f1000research.10817.1. eCollection 2017. Review. PubMed PMID: 28690839; PubMed Central PMCID: PMC5482325

RMajithia N, Smith TJ, Coyne PJ, Abdi S, Pachman DR, Lachance D, Shelerud R, Cheville A, Basford JR, Farley D, O'Neill C, Ruddy KJ, Sparadeo F, Beutler A, Loprinzi CL. Scrambler Therapy for the management of chronic pain. Support Care Cancer. 2016 Jun;24(6):2807-14. doi: 10.1007/s00520-016-3177-3. Epub 2016 Apr 4. Review. PubMed PMID: 27041741; PubMed Central PMCID: PMC497


Clinical Trials

Smith T, Cheville AL, Loprinzi CL, Longo-Schoberlein D. Scrambler Therapy for the Treatment of Chronic Post-Mastectomy Pain (cPMP). Cureus. 2017 Jun21;9(6):e1378. doi: 10.7759/cureus.1378. PubMed PMID: 28775918; PubMed Central PMCID: PMC5522013

Kashyap K, Joshi S, Vig S, Singh V, Bhatnagar S. Impact of Scrambler Therapy on Pain Management and Quality of Life in Cancer Patients: A Study of Twenty Cases. Indian J Palliat Care. 2017 Jan-Mar;23(1):18-23. doi: 10.4103/0973-1075.197948.
Erratum in: Indian J Palliat Care. 2017 Apr-Jun;23(2):217. PubMed PMID: 28216858; PubMed Central PMCID: PMC52944323603.

Raucci U, Tomasello C, Marri M, Salzano M, Gasparini A, Conicella E. Scrambler Therapy(®) MC-5A for Complex Regional Pain Syndrome: Case Reports. Pain Pract. 2016 Jul 2. doi: 10.1111/papr.12474. [Epub ahead of print] PubMed PMID: 27370908

Smith TJ, Auwaerter P, Knowlton A, Saylor D, McArthur J. Treatment of human immunodeficiency virus-related peripheral neuropathy with Scrambler Therapy: a case report. Int J STD AIDS. 2016 Jun 21. pii: 0956462416656688. [Epub ahead of print] PubMed PMID: 27330020

Majithia N, Smith TJ, Coyne PJ, Abdi S, Pachman DR, Lachance D, Shelerud R,Cheville A, Basford JR, Farley D, O'Neill C, Ruddy KJ, Sparadeo F, Beutler A,Loprinzi CL. Scrambler Therapy for the management of chronic pain. Support Care Cancer. 2016 Apr 4. [Epub ahead of print] Review. PubMed PMID: 27041741.

Compagnone C, Tagliaferri F, Amato F, Ballerini G, Berlinghieri F, Bertini L, Bordin G, Buonavolontà P, Cascioli A, Ceccaroni F,Cautillo A,Ciaschi A, Dodaro LM,Fanelli G, Greco F, Lesignoli P,Martini O,Papa A, Quatrone D, Raffaeli W, Mediati R, Velluci R. Chronic pain treatment and scrambler therapy: a multicenter retrospective analysis. Acta Biomed. 2015 Sep 14;86(2):149-156. PubMed PMID: 26422429.

Notaro P, Dell'Agnola CA, Dell'Agnola AJ, Amatu A, Bencardino KB, Siena S. Pilot evaluation of scrambler therapy for pain induced by bone and visceral metastases and refractory to standard therapies. Support Care Cancer. 2015 Sep 26. [Epub ahead of print] PubMed PMID: 26408323.

Smith TJ, Marineo G. Treatment of Postherpetic Pain With Scrambler Therapy, a Patient-Specific Neurocutaneous Electrical Stimulation Device. Am J Hosp PalliatCare. 2013 Jul 8.[Epub ahead of print] PubMed PMID: 23838448.

Marineo G. Inaccuracy in the article "Managing chronic pain: results from an open-label study using MC5-A Calmare device in Support Care Cancer". Support Care Cancer. 2011 Oct;19(10):1483-4.Epub 2011 Aug 2. PubMed PMID: 21808993.

Marineo G, Iorno V, Gandini C, Moschini V, Smith TJ. Scrambler Therapy May Relieve Chronic Neuropathic Pain More Effectively Than Guideline-Based Drug Management: Results of a Pilot, Randomized, Controlled Trial. J Pain Symptom Manage. 2011 Jul 13. Epub ahead of print PubMed PMID: 21763099.

Smith TJ, Coyne PJ, Parker GL, Dodson P, Ramakrishnan V. Pilot trial of a patient-specific cutaneous electrostimulation device (MC5-A Calmare®) for chemotherapy-induced peripheral neuropathy. J Pain Symptom Manage. 2010 Dec;40(6):883-91. PubMed PMID: 20813492.

Sabato AF, Marineo G, Gatti A. Scrambler therapy. Minerva Anestesiol. 2005 Jul-Aug;71(7-8):479-82. PubMed PMID: 16012423.

Marineo G. Untreatable pain resulting from abdominal cancer: new hope from biophysics? JOP. 2003 Jan;4(1):1-10. PubMed PMID: 12555009.


Delta-S Entropy Variation System - Selected References

Marineo G, Fesce E. Biophysics and clinical practice for regenerative processes in cirrhosis of the liver/of liver cirrhosis assisted by Delta-S Entropy Variation Systems. Minerva Gastroenterol Dietol. 2006 Dec;52(4):365-70. PubMed PMID: 17108866.

Marineo G, Marotta F. Delta-S entropy variation system: a novel biophysical approach to treat chronic-degenerative processes. The challenge of liver cirrhosis. Saudi Med J. 2004 Aug;25(8):979-82. Review. PubMed PMID: 15322583.

Marineo G, Marotta F, Sisti G. Cirrhosis progression as a model of accelerated senescence: affecting the biological aging clock by a breakthrough biophysical methodology. Ann N Y Acad Sci. 2004 Jun;1019:572-6. PubMed PMID: 15247089.

Conferences

Biophysics of aging and therapeutic interventions by entropy-variation systems.
G. Marineo. Delta Research & Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy.
2nd World Congress on Regenerative Medicine, 18-20 May 2005,Germany Congress Center, Leipzig

Biophysics behind regenerative processes. A pilot study on the treatment of gross scar tissue using a breakthrough entropy variation system.
G. Marineo, F. Marotta.Delta Research & Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy. 4Th European Congress of Biogerontology, 7 November 2004, Newcastle Upon Tyne, United Kingdom

Can biophysics counteract age-related biological decay? An innovative technique tackling the progression of liver cirrhosis as a model of accelerated senescence.
G. Marineo, F. Marotta.Delta Research & Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy
International Conference on Functional Genomics of Ageing, April 28-May 1 2004, Creta, Grecia.

Biophysics interventions where biology fails: a breakthrough biophysical methodology counteracting cirrhosis progression.
G. Marineo, F. Marotta, G. Sisti. Delta Research & Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy. Asia Pacific Digestive Week 2004, April 20 - 24, 2004,, Chinese Medical Association, Beijing, China

The biophysics option: a pilot study on functional recovery of immunodeficiency. 6th World Congress on Trauma, Shock, Inflammation and Sepsis - Pathophysiology, Immune consequences and Therapy.
G. Marineo, F. Marotta. Delta Research & Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy.March2-6, 2004, Munich, Germany. Shock 2004; suppl vol 21;133

Decoding the biological clock by an innovative biophysical methodology: taking the challenge of cirrhosis progression as a model of accelerated senescence.
G. Marineo, F. Marotta, G. Sisti. Delta Research & Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy.Anti-Aging Conference & Exposition, December 12-14, 2003, Las Vegas, USA.

Physiological aging process and functional reserve. Preliminary study with a non invasive biophysical antiaging approach.
G.Marineo, F.Marotta. Delta Research & Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy
The 7th Asia/Oceania Regional Congress of Gerontology, November 24-28,2003, Tokyo International Forum, Tokyo, Japan

An Innovative Biophysical Method Counteracting Cirrhosis Progression: Optimizing Transplantation Programs and Supporting Candidates Excluded from Surgery.
G.Marineo, F.Marotta, G.Sisti.Delta Research & Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy. Second JSH Single Topic Conference "Progress and Future Perspective in Adult Living Donor Liver Transplantation",October 13-14, 2003 at Lake Biwa, Shiga, Japan

Cirrhosis progression as a model of accelerated senescence :affecting the biological aging clock by a breakthrough biophysical methodology.
G. Marineo, F. Marotta, G. Sisti.Delta Research & Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy.The International Association of Biomedical Gerontology 10th Congress Strategies for Engineered Negligible Senescence: Reasons Why Genuine Control of Aging may be Foreseeable. Queens' College, Cambridge, England 19-23 September 2003

Physiological aging process and functional reserve. Preliminary study with a non-invasive biophysical antiaging approach.
G. Marineo, F. Marotta. Delta Research & Development, Research Center for Medical Bioengineering.
Selected presentation at the Anti-Aging World Conference 2003,Feb. 28- March 2, Paris, France".

An innovative biophysical approach to aging of immune system. A pilot study on functional recovery of secondary immunodeficiency.
G. Marineo, F. Marotta.Delta Research & Development, Research Center for Medical Bioengineering
Selected for Presentation at the Fourth Annual Conference On Regenerative Medicine, NOVEMBER 17 – 19, 2003, Renaissance Hotel in Washington, D. C.

Preliminary study with an experimental biophysical liver cirrhosis treatment.
G. Marineo, F. Marotta.Delta Research & Development, Research Center for Medical Bioengineering.
Invited Lecture at Shiga University - Dept. of Internal Medicine - Gastroenterology (Prof. T. Bamba, President of Japanese Society of Gastroenterology"), November 13 2002 , Otsu, Japan.

Biophysics-induced tissue regeneration. A pilot study using “Delta-S” Entropy Variation System on Burns Sequelae and Keloids.
1)Marineo, G, 2)Indrizzi, E, Gasparini, G , Terenzi, V. , 3)Fini, G., 1)Marotta, F.
(1) Delta Research & Development, Medical Bioengineering Research Centre -”University of Rome Tor Vergata”, (2) Maxillo-Facial Surgery Dept., University of Rome “La Sapienza”, (3) S. Andrea Hospital, Faculty of Medicine , University of Rome “La Sapienza ”.

This work was awarded the Outstanding Paper Prize at the 19th Kumamoto Medical Bioscience Symposium: Cellular, Molecular and Genetic Aspects of Biological Response to Planned and Unplanned Injury, 7-8 November, 2002, Kumamoto, Japan

Biophysic and aging of immune system. A pilot study on functional recovery of immunodeficiency due to aging and chronic activation-induced stress.
G.Marineo, F.Marotta.Delta Research & Development, Research Center for Medical Bioengineering.1st Asia Pacif Conference & Exhibition on Anti Ageing Medicine 2002 - June 23-26, 2002 Singapore

Physiological aging process and functional reserve. Preliminary study with an experimental biophysical antiaging treatment.
G.Marineo. Delta Research & Development, Research Center for Medical Bioengineering. 1st Asia Pacif Conference & Exhibition on Anti Ageing Medicine 2002 - June 23-26, 2002 Singapore

QOL in end-stage diseases o in terminal care.
G.Marineo. Delta Research & Development, Research Center for Medical Bioengineering, Tor Vergata University, Rome, Italy
Invited chairperson for the session "End of Life" at the 7thhe 7th Asia/Oceania Regional Congress of Gerontology, November 24-28,2003, Tokyo International Forum, Tokyo, Japan

The biophysical frontier: an innovative option for an optimal palliative care of "untreatable" cancer pain.
G. Marineo (1), S. Spaziani (2), A.F. Sabato (3), F.Marotta (1)
(1) Delta Research & Development, Research Center for Medical Bioengineering
(2) Pain Service, Umberto I Hospital – Frosinone
(3) Surgery Dept., University of Rome Tor Vergata, Pain Service.
The 7th Asia/Oceania Regional Congress of Gerontology, November 24-28,2003, Tokyo International Forum, Tokyo, Japan

Toward a better palliative QOL control in cancer patients: a novel biophysic method to control "untreatable" pain
G. Marineo (1), S. Spaziani (2), A.F. Sabato (3), F.Marotta (1)
(1) Delta Research & Development, Research Center for Medical Bioengineering
(2) Pain Service, Umberto I Hospital – Frosinone
(3) Surgery Dept., University of Rome Tor Vergata, Pain Service.
Invited Lecture at the 6th International Congress of Gastrointestinal Surgery & Hepatology, March 12-15, 2003, Luxor, Egypt.

Untreatable pancreatic cancer pain: the potential of Scrambler Therapy
G. Marineo, F. Marotta
Delta Research & Development, Research Center for Medical Bioengineering.Invited lecture at Kanazawa University Hospital, Cancer Research Institute, Dept. Internal Medicine & Oncology (Prof. N. Sawabu),November 11 2002, Kanazawa, Japan.

Artificial Neurons in oncological pain: the potential of Scrambler Therapy to modify a biological information.
G. Marineo (1), S. Spaziani (2), A.F. Sabato (3), F.Marotta (1)
(1) Delta Research & Development, Research Center for Medical Bioengineering
(2) Pain Service, Umberto I Hospital – Frosinone
(3) Surgery Dept., University of Rome Tor Vergata, Pain Service.

This work was awarded the Outstanding Paper Prize at the 19th Kumamoto Medical Bioscience Symposium: Cellular, Molecular and Genetic Aspects of Biological Response to Planned and Unplanned Injury, 7-8 November, 2002, Kumamoto, Japan

Artificial neurons and the role of information in the oncological pain: the potential of Scrambler Therapy.
G. Marineo (1), S. Spaziani (2), A.F. Sabato (3), F.Marotta (1)
(1) Delta Research & Development, Research Center for Medical Bioengineering
(2) Pain Service, Umberto I Hospital – Frosinone
(3) Surgery Dept., University of Rome Tor Vergata, Pain Service.
Invited Communication at the 33rd Annual Meeting of the Japan Pancreas Society, 4-5 settembre, Sendai, Giappone".

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